I don't know why do you think that about the connections. Thinking of your environment, you can have a single LUN, for example, of 1 TB formatted with VMs and storing a lot of VMDKs - and you will need only the connection from the ESX to the LUN (which is 1 or 2 or more if you have more paths, but nothing above 4). The number of VMDKs does not impact on the number of iSCSI connections and/or paths you have.
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